Abstract

Colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant Acinetobacter baumannii.

Shrestha, Gentle Sunder Tamang, Sushil Paneru, Hem Raj Shrestha, Pramesh Sunder Keyal, Niraj Acharya, Subhash Prasad Marhatta, Moda Nath Shilpakar, Sushil

Abstract


Acinetobacter baumannii is an important cause of nosocomial ventriculitis associated with external ventricular device (EVD). It is frequently multidrug resistant (MDR), carries a poor outcome, and is difficult to treat. We report a case of MDR Acinetobacter ventriculitis treated with intravenous and intraventricular colistin together with intravenous tigecycline. The patient developed nephrotoxicity and poor neurological outcome despite microbiological cure. Careful implementation of bundle of measures to minimize EVD-associated ventriculitis is valuable.


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