Abstract
Background:: Changes in platelet indices have been reported in patients with panic disorder (PD). However, previous study findings are contradictory and inconclusive. The aim of this study was to evaluate and compare the platelet indices in patients with PD. Materials and Methods:: Patients with PD (n = 123) and healthy controls (n = 133) were enrolled in this case control study. The platelet indices (mean platelet volume [MPV] and platelet distribution width [PDW]) along with red blood cell (RBC) indices (RBC count and red cell distribution width [RDW]) were compared between the two groups using the unpaired t-test. Results:: Patients with PD had lower MPV (7.53 0.93 fL vs. 8.91 1.24 fL, P < 0.0001), higher PDW (16.96 0.85 fL vs. 14.71 2.07 fL, P < 0.0001), and higher platelet count (274.2 80.66 109 L1 vs. 243.1 93.89 109 L1, P < 0.005) than the healthy controls. Furthermore, there were significant differences between patients with PD and healthy controls in terms of their RBC count (4.32 0.56 1012 L1 vs. 4.08 0.80 1012 L1, P = 0.007) and RDW (16.48 2.26 fL vs. 15.01 2.25 fL, P < 0.0001). Conclusion:: Patients with PD have increased PDW and RDW. The platelet and RBC indices may prove to be useful etiological and prognostic markers in patients with PD.
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This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
