Abstract
BACKGROUND: Diagnosis of cerebral small vessel disease (SVD) is a challenge in remote areas where magnetic resonance imaging (MRI) is not available. Hospital-based studies in high-risk or stroke patients have found an association between the pulsatility index (PI) of intracranial arteries - as derived from transcranial Doppler (TCD) - and white matter hyperintensities (WMH) of presumed vascular origin. We aimed to assess the reliability of cerebral pulsatility indices to identify candidates for MRI screening in population-based studies assessing prevalence of SVD. METHODS: A representative sample of stroke-free Atahualpa residents aged >/=65 years investigated with MRI underwent TCD. Using generalized linear models, we evaluated whether the PI of major intracranial arteries correlate with WMH (used as a proxy of diffuse SVD), after adjusting for demographics and cardiovascular risk factors. RESULTS: Out of 70 participants (mean age 70.6 +/- 4.6 years, 57% women), 28 (40%) had moderate-to-severe WMH. In multivariate models, there were no differences across categories of WMH in the mean PI of middle cerebral arteries (1.10 +/- 0.16 vs. 1.22 +/- 0.24, beta: 0.065, 95% confidence interval (CI): -0.084-0.177, P = 0.474) or vertebrobasilar arteries (1.11 +/- 0.16 vs. 1.29 +/- 0.27, beta: 0.066, 95% CI: -0.0024-0.156, P = 0.146). CONCLUSIONS: Cerebral PI should not be used to identify candidates for MRI screening in population-based studies assessing the burden of SVD.
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